What question did this study set out to answer?

The study aims to understand how carotid baroreceptors influence vascular responses during chemoreceptor stimulation in dogs.

February 1, 1975Circulation ResearchOpen Access

Influence of carotid baroreceptors on vascular responses to carotid chemoreceptor stimulation in the dog.

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Population

Anesthetized, artificially ventilated, vagotomized dogs

Comparison

Carotid chemoreceptor stimulation by perfusion… vs Responses at intermediate versus maximal and…

Design

Preclinical

Authors

GMGiuseppe ManciaGeneral Cardiology

Discussion

Member takes

Implication

Central baroreceptor-chemoreceptor interaction shown in animals; leaves open relevance to human autonomic cardiovascular control.

Key Points

The study aims to understand how carotid baroreceptors influence vascular responses during chemoreceptor stimulation in dogs.
Studied anesthetized, artificially ventilated, vagotomized dogs with vascularly isolated carotid bifurcations.
Carotid bifurcations were perfused at consistent pressures to evaluate the effects of vasomotor center inhibition.
Analyzed the effects of chemoreceptor stimulation using hypoxic hypercapnic blood.
Intermediate inhibition increased aortic pressure by 50% and reduced blood flow to hind-limb and kidney by 59% and 19%, respectively.
At maximum and minimum carotid sinus pressures (215 and 51 mm Hg), the vascular responses to chemoreceptor stimulation were absent or significantly reduced.
During intermediate sinus pressure, chemoreceptor stimulation decreased the saphenous vein perfusion pressure by 27%.

Structured PICO

Population

Anesthetized, artificially ventilated, vagotomized dogs

Intervention

Carotid chemoreceptor stimulation by perfusion with hypoxic hypercapnic blood at varying carotid sinus pressures (134, 215, and 51 mm Hg)

Comparator

Responses at intermediate (134 mm Hg) versus maximal (215 mm Hg) and minimal (51 mm Hg) carotid sinus pressures

Outcome

Vascular responses including aortic pressure, hind-limb blood flow, kidney blood flow, and saphenous vein perfusion pressuresurrogate

Vascular responses to carotid chemoreceptor stimulation are inhibited when carotid sinus baroreceptor activity is maximal or minimal, indicating a central interaction between chemoreceptor and baroreceptor inputs.

Cite This Study

Giuseppe Mancia (1975) studied this question.

synapsesocial.com/papers/6a128d33c031bb6829a6dba6 https://doi.org/10.1161/01.res.36.2.270

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Influence of carotid baroreceptors on vascular responses to carotid chemoreceptor stimulation in the dog.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Influence of carotid baroreceptors on vascular responses to carotid chemoreceptor stimulation in the dog.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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