What is the clinical evidence from this study?

Study design: Other. Intervention: Changes in arterial pressure and baroreceptor activation. Primary outcome: Ventilatory response to chemoreceptor stimulation.

What question did this study set out to answer?

To determine whether variations in arterial blood pressure and baroreceptor activation modulate ventilatory responses elicited by carotid chemoreceptor stimulation.

September 1, 1975Journal of Applied Physiology

Effect of baroreceptor activity on ventilatory response to chemoreceptor stimulation

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Key result

Ventilatory responses to chemoreceptor stimulation were augmented by hypotension and depressed by hypertension, indicating a central interaction between baroreceptor and chemoreceptor reflexes.

Why the study?

Does baroreceptor activation modulate ventilatory responses to chemoreceptor stimulation in anesthetized dogs?

Population

Anesthetized dogs

Comparison

Alteration of arterial pressure and isolated… vs Baseline arterial pressure or constant perfusion…

Design

Preclinical

Authors

HDHeistad Dd FAFrançois M. AbboudGeneral Cardiology AMAllyn L. MarkGeneral Cardiology

Discussion

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Implication

Findings from anesthetized dogs do not inform practice; leaves open human translation of central baroreceptor-chemoreceptor interactions.

Key Points

To determine whether variations in arterial blood pressure and baroreceptor activation modulate ventilatory responses elicited by carotid chemoreceptor stimulation.
Stimulated carotid chemoreceptors with nicotine injections in anesthetized dogs during hypotension induced by hemorrhage and hypertension induced by transient abdominal aortic occlusion.
Employed an isolated dual-carotid perfusion preparation at constant flow to independently raise pressure in one carotid bifurcation (baroreceptor activation) while stimulating the contralateral chemoreceptors with nicotine, evaluated before and after bilateral vagotomy.
Ventilatory responses to chemoreceptor activation were augmented during systemic hypotension and suppressed during systemic hypertension.
Selective unilateral baroreceptor stimulation attenuated ventilatory responses triggered by contralateral chemoreceptor excitation, an inhibitory effect that persisted following bilateral cervical vagotomy.

Structured PICO

Does baroreceptor activation modulate ventilatory responses to chemoreceptor stimulation in anesthetized dogs?

Population

Anesthetized dogs undergoing carotid chemoreceptor stimulation via nicotine injection to assess ventilatory responses to changes in arterial pressure.

Intervention

Alteration of arterial pressure (hypotension via bleeding, hypertension via transient occlusion of the abdominal aorta) and isolated stimulation of carotid sinus baroreceptors

Comparator

Baseline arterial pressure or constant perfusion pressure

Outcome

Ventilatory response to chemoreceptor stimulation (via nicotine injection)surrogate

This study demonstrates a major central interaction between baroreceptor and chemoreceptor reflexes, where changes in baroreceptor activity modulate ventilatory responses to chemoreceptor stimulation.

Cite This Study

Dd et al. (1975) studied this question. Changes in arterial pressure and baroreceptor activation was evaluated on Ventilatory response to chemoreceptor stimulation. Ventilatory responses to chemoreceptor stimulation were augmented by hypotension and depressed by hypertension, indicating a central interaction between baroreceptor and chemoreceptor reflexes.

synapsesocial.com/papers/6a1eff90459b8c409ce6b79e https://doi.org/10.1152/jappl.1975.39.3.411

Topics

Hypertension management

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Effect of baroreceptor activity on ventilatory response to chemoreceptor stimulation

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Effect of baroreceptor activity on ventilatory response to chemoreceptor stimulation

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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Topics

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