Key result
Increases in arterial pressure significantly inhibited carotid sinus nerve-evoked discharge in NTS neurons to 67% of control (P<0.01), demonstrating baroreceptor attenuation of chemoreceptor inputs.
Population
Pentobarbital sodium-anesthetized, mechanically ventilated, paralyzed cats (n=70 NTS neurons recorded)
Comparison
Increases in arterial pressure during brief… vs Control-evoked discharge at the prevailing level…
Design
Preclinical
Authors
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Should not alter clinical practice; hypothesis-generating for NTS-level baroreceptor-chemoreflex integration in humans.
p-value: p=< 0.01
Activation of arterial baroreceptors attenuates excitatory chemoreceptor inputs to a subpopulation of NTS neurons, indicating that baroreceptor modulation of arterial chemoreflexes occurs at an early stage of the reflex arc.
Steven W. Mifflin (1993) studied this question. Increases in arterial pressure (baroreceptor stimulation) vs. Control-evoked discharge at prevailing arterial pressure was evaluated on Carotid sinus nerve (CSN)-evoked discharge of NTS neurons (p=< 0.01). Increases in arterial pressure significantly inhibited carotid sinus nerve-evoked discharge in NTS neurons to 67% of control (P<0.01), demonstrating baroreceptor attenuation of chemoreceptor inputs.
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