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September 15, 1995The Journal of PhysiologyOpen Access

Hypothalamic modulation of the arterial chemoreceptor reflex in the anaesthetized cat: role of the nucleus tractus solitarii.

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Key result

Stimulation of the hypothalamic defence area elicited an EPSP in 16 of 18 chemosensitive NTS neurones, demonstrating synaptic interactions between arterial chemoreceptors and the HDA within the NTS.

Population

Anaesthetized, paralysed and artificially ventilated cats

Design

Preclinical

Authors

LSL Silva-CarvalhoUniversity of LisbonMDMarc Stefan Dawid-MilnerUniversidad de MálagaGGG E GoldsmithThe Royal Free Hospital

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Implication

Hypothesis-generating for NTS integration of defence and chemoreflex inputs; extends basic models but leaves open translation to humans.

Structured PICO

P
Population
18 NTS neurones recorded in anaesthetized, paralysed and artificially ventilated cats.
I
Intervention
Stimulation of the arterial chemoreceptors and the hypothalamic defence area (HDA)
O
Outcome
Activity of NTS neurones (synaptic interactions, EPSPs, IPSPs)surrogate

The study demonstrates that the nucleus tractus solitarii integrates convergent inputs from arterial chemoreceptors and the hypothalamic defence area, providing a mechanistic basis for their interaction in cardiorespiratory control.

Cite This Study

Silva-Carvalho et al. (1995) studied this question. Stimulation of the arterial chemoreceptors and the hypothalamic defence area (HDA) was evaluated on Activity of NTS neurones (EPSPs/IPSPs). Stimulation of the hypothalamic defence area elicited an EPSP in 16 of 18 chemosensitive NTS neurones, demonstrating synaptic interactions between arterial chemoreceptors and the HDA within the NTS.

synapsesocial.com/papers/6a6b72b8050bc01bbbcb6841https://doi.org/10.1113/jphysiol.1995.sp020915
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Arterial chemoreceptor input to nucleus tractus solitarius1992 · 135 citations
  2. 2The pattern of excitatory inputs to the nucleus tractus solitarii evoked on stimulation in the hypothalamic defence area in the cat.1995 · 44 citations
  3. 3The central projections of carotid baroreceptors and chemoreceptors in the cat: a neurophysiological study.1984 · 216 citations
  4. 4The baroreceptor input to cardiac vagal motoneurones1978 · 185 citations
  5. 5Excitatory and inhibitory interactions among renal and cardiovascular afferent nerves in dorsomedial medulla1986 · 33 citations