March 1, 2009Tzu Chi Medical JournalOpen Access

Neurotransmission of the Peripheral Chemoreflex in the Nucleus Tractus Solitarii in Unanesthetized Experimental Models

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Population

Awake rats and working heart brainstem preparation (WHBP) models

Design

Review

Authors

BMBenedito H. MachadoUniversidade de Ribeirão Preto

Discussion

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Implication

May implicate NTS glutamatergic-purinergic signaling in chemoreflex sympathoexcitation; leaves open translation to human cardiorespiratory disease.

Structured PICO

Population

Awake rats and working heart brainstem preparation (WHBP) models

Intervention

Simultaneous antagonism of ionotropic glutamate receptors and purinergic P2 receptors by sequential microinjections of kynurenic acid and PPADS into the nucleus tractus solitarii (NTS)

Outcome

Pressor response, sympathoexcitation, bradycardia, and tachypnea to peripheral chemoreflex activationsurrogate

This review highlights that both glutamatergic and purinergic mechanisms in the NTS are required for the sympathoexcitatory component of the peripheral chemoreflex.

Cite This Study

Benedito H. Machado (2009) studied this question.

synapsesocial.com/papers/6a8804c24c82be800eeb398b https://doi.org/10.1016/s1016-3190(09)60002-1

View Full Paper

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Implication

May implicate NTS glutamatergic-purinergic signaling in chemoreflex sympathoexcitation; leaves open translation to human cardiorespiratory disease.

Neurotransmission of the Peripheral Chemoreflex in the Nucleus Tractus Solitarii in Unanesthetized Experimental Models

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Neurotransmission of the Peripheral Chemoreflex in the Nucleus Tractus Solitarii in Unanesthetized Experimental Models

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider