February 2, 2006Experimental Physiology

Chemoreflex sympathoexcitation was not altered by the antagonism of glutamate receptors in the commissural nucleus tractus solitarii in the working heart–brainstem preparation of rats

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Population

Working heart-brainstem preparation of rats (n=23)

Comparison

Bilateral microinjections of glutamate receptor… vs Baseline (before microinjections)

Design

Preclinical

Follow-up

up to 10 minutes

Authors

VBValdir A. BragaUniversidade Federal da Paraíba BMBenedito H. MachadoUniversidade de Ribeirão Preto

Discussion

Member takes

Implication

Supports selective parasympathetic targeting in preclinical chemoreflex models; leaves open translation to human autonomic therapies.

Structured PICO

Population

Working heart-brainstem preparation of rats (n=23)

Intervention

Bilateral microinjections of glutamate receptor antagonists (kynurenic acid [KYN, 250 mM], (+/-)-alpha-methyl-4-carboxyphenylglycine [MCPG, 100 mM], or KYN plus MCPG) into the commissural nucleus tractus solitarii (cNTS)

Comparator

Baseline (before microinjections)

Outcome

Changes in thoracic sympathetic nerve activity, heart rate, and frequency of phrenic nerve discharge in response to chemoreflex activationsurrogate

The parasympathetic component of the chemoreflex in the cNTS is mediated by L-glutamate, while sympathoexcitatory and respiratory components involve other neurotransmitters.

Cite This Study

Braga et al. (2006) studied this question.

synapsesocial.com/papers/6a85455564694fc428d97d35 https://doi.org/10.1113/expphysiol.2005.033100

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