Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
April 27, 2012Journal of NeurophysiologyOpen Access

Sympathoexcitation during chemoreflex active expiration is mediated byl-glutamate in the RVLM/Bötzinger complex of rats

View Full Paper
Ask AI
Bookmark
Share

Population

Working heart-brain stem preparation of juvenile rats

Comparison

Bilateral microinjections of kynurenic acid into… vs Pre-injection baseline responses to chemoreflex…

Design

Preclinical

Authors

DMDavi J. A. MoraesDZDaniel B. ZoccalBMBenedito H. Machado

Discussion

Loading...

Member takes

Overview

May elucidate brainstem coupling of respiration and sympathetic drive in rats; leaves open translation to human cardiorespiratory disease.

Structured PICO

P
Population
Working heart-brain stem preparation of juvenile rats
I
Intervention
Bilateral microinjections of kynurenic acid (KYN) into the rostral aspect of RVLM (RVLM/BötC) or caudal aspect (RVLM/pre-BötC)
C
Comparator
Pre-injection baseline responses to chemoreflex activation
O
Outcome
Sympathoexcitatory and respiratory (phrenic, hypoglossal, abdominal, vagal) responses to peripheral chemoreflex activationsurrogate

Ionotropic glutamate receptors in the RVLM/BötC are essential for coupling active expiration and sympathoexcitatory responses during chemoreflex activation in rats.

Cite This Study

Moraes et al. (2012) studied this question.

synapsesocial.com/papers/6a7ca982e6f41aaf0bcf8285https://doi.org/10.1152/jn.00057.2012
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Tonic sympathetic chemoreflex after blockade of respiratory rhythmogenesis in the rat.1996 · 131 citations
  2. 2Modulation of the sympathetic response to acute hypoxia by the caudal ventrolateral medulla in rats2008 · 57 citations
  3. 3Central respiratory modulation of medullary sympathoexcitatory neurons in rat1989 · 176 citations
  4. 4Tonic Glutamatergic Input in the Rostral Ventrolateral Medulla Is Increased in Rats With Chronic Heart Failure2008 · 56 citations
  5. 5Increased sympathetic outflow in juvenile rats submitted to chronic intermittent hypoxia correlates with enhanced expiratory activity2008 · 256 citations