March 30, 2007The Journal of PhysiologyOpen Access

Involvement of l‐glutamate and ATP in the neurotransmission of the sympathoexcitatory component of the chemoreflex in the commissural nucleus tractus solitarii of awake rats and in the working heart–brainstem preparation

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Population

Awake rats and working heart-brainstem preparation models

Comparison

Simultaneous blockade of ionotropic glutamate… vs Control microinjections of saline

Design

Preclinical

Authors

VBValdir A. BragaUniversidade Federal da Paraíba RSRenato Nery SorianoUniversidade Federal de Juiz de Fora ABAlex L. BraccialliUniversidade de São Paulo

Discussion

Member takes

Implication

Glutamatergic and purinergic NTS signaling mediate chemoreflex in rats; extends mechanistic insight but leaves open human translation.

Structured PICO

Population

Awake rats and working heart-brainstem preparation (WHBP) models (n=13 for cardiovascular responses, n=7 for respiratory responses)

Intervention

Simultaneous blockade of ionotropic glutamate receptors and P2 receptors by sequential microinjections of kynurenic acid (KYN) and pyridoxalphosphate-6-azophenyl-2',4'-disulphonate (PPADS) into the commissural nucleus tractus solitarii (NTS)

Comparator

Control microinjections of saline

Outcome

Pressor response and bradycardic response following peripheral chemoreflex activation with potassium cyanide (KCN)surrogate

Glutamatergic and purinergic mechanisms in the commissural NTS are both required for the sympathoexcitatory and bradycardic responses to peripheral chemoreflex activation.

Cite This Study

Braga et al. (2007) studied this question.

synapsesocial.com/papers/6a8154dc267334e2baf092fd https://doi.org/10.1113/jphysiol.2007.129031

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Involvement of l‐glutamate and ATP in the neurotransmission of the sympathoexcitatory component of the chemoreflex in the commissural nucleus tractus solitarii of awake rats and in the working heart–brainstem preparation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Involvement of l‐glutamate and ATP in the neurotransmission of the sympathoexcitatory component of the chemoreflex in the commissural nucleus tractus solitarii of awake rats and in the working heart–brainstem preparation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider