October 1, 1995AJP Heart and Circulatory Physiology

NMDA receptors in NTS are involved in bradycardic but not in pressor response of chemoreflex

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Population

Unanesthetized rats

Design

Preclinical

Authors

AHAndréa Siqueira HaibaraUniversidade Federal de Minas Gerais ECEduardo ColombariFundação Faculdade de Odontologia DCDeoclécio Alves ChiancaUniversidade Federal de Ouro Preto

Discussion

Member takes

Implication

Extends rodent chemoreflex mechanisms; hypothesis-generating with no implications for clinical practice.

Structured PICO

Population

Unanesthetized rats

Intervention

Microinjection of phosphonovaleric acid (AP-5), an NMDA-selective antagonist, into the commissural nucleus tractus solitarii (NTS) at three different doses, combined with intravenous potassium cyanide (KCN) to activate carotid chemoreceptors

Outcome

Cardiovascular (pressor and bradycardic) and respiratory (ventilatory frequency) responses to chemoreceptor activationsurrogate

The cardiovagal component of the chemoreflex in the commissural NTS is mediated by NMDA receptors, whereas the pressor and ventilatory components are not.

Cite This Study

Haibara et al. (1995) studied this question.

synapsesocial.com/papers/6a8804c34c82be800eeb398d https://doi.org/10.1152/ajpheart.1995.269.4.h1421

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NMDA receptors in NTS are involved in bradycardic but not in pressor response of chemoreflex

Discussion

Member takes

Implication

Structured PICO

Cite This Study

NMDA receptors in NTS are involved in bradycardic but not in pressor response of chemoreflex

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider