Key result
Microinjections of 5-HT or the 5-HT3 agonist CPBG into the NTS dose-dependently blocked KCN-induced chemoreflex bradycardia, an effect prevented by 5-HT3 or GABA(A) antagonists.
Population
Anesthetized rats
Comparison
Microinjections of 5-HT or the 5-HT3 agonist… vs Prior intra-NTS microinjection of 5-HT3…
Design
Preclinical
Authors
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NTS 5-HT3 stimulation inhibits chemoreflex bradycardia via GABA in rats; leaves open translation to human autonomic cardiovascular control.
Stimulation of 5-HT3 receptors in the NTS exerts an inhibitory influence on the cardiovagal component of the chemoreflex, likely via a local GABAergic system.
Callera et al. (1997) studied this question. 5-HT or 5-HT3 agonist CPBG microinjections into the commissural NTS was evaluated on Cardiovagal, sympathetic, and respiratory responses to activation of carotid body chemoreceptors. Microinjections of 5-HT or the 5-HT3 agonist CPBG into the NTS dose-dependently blocked KCN-induced chemoreflex bradycardia, an effect prevented by 5-HT3 or GABA(A) antagonists.
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