Key result
Ionophoretic application of the 5-HT3 agonist PBG increased NTS neurone activity from 2.4 to 5.5 spikes/s, an effect significantly attenuated by the antagonist granisetron.
Population
Anaesthetized rats (recordings from 301 nucleus tractus solitarius neurones)
Comparison
Ionophoretic application of phenylbiguanide… vs Baseline activity or control conditions
Design
Preclinical
Authors
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Central 5-HT3 receptors modulate rat NTS vagal inputs; leaves open translation to human cardiovascular reflexes.
Vagal inputs to the NTS utilize a 5-HT-containing pathway that activates 5-HT3 receptors, partly through direct postsynaptic action and partly by facilitating glutamate release.
Jeggo et al. (2005) studied Anaesthetized rats (animal study). Phenylbiguanide (PBG) and granisetron vs. Baseline was evaluated on NTS neurone activity (spikes/s). Ionophoretic application of the 5-HT3 agonist PBG increased NTS neurone activity from 2.4 to 5.5 spikes/s, an effect significantly attenuated by the antagonist granisetron.
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