November 1, 2002British Journal of PharmacologyOpen Access

Modulation of reflexly evoked vagal bradycardias by central 5‐HT1A receptors in anaesthetized rabbits

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Population

Atenolol-pretreated anaesthetized rabbits

Design

Preclinical

Authors

MSMatthew SkinnerAstraZeneca (United Kingdom)ARAndrew G. RamageGold Coast Health DJDavid L. JordanNorth Carolina State University

Discussion

Member takes

Implication

No immediate clinical implications; leaves open further investigation of central 5-HT1A receptors in human autonomic reflexes.

Structured PICO

Population

Atenolol-pretreated anaesthetized rabbits

Intervention

Buspirone (100 micro g kg(-1); i.c. or i.v.) and/or WAY-100635 (100 micro g kg(-1); i.v. or i.c.)

Outcome

Bradycardia (increase in R-R interval) and changes in central respiratory drive, renal nerve activity and blood pressure evoked by stimulating cardiopulmonary afferents, baroreceptors, and chemoreceptorssurrogate

Central 5-HT1A receptors play a role in the reflex activation of cardiac preganglionic vagal motoneurones, with differential effects on chemoreceptor pathways compared to cardiopulmonary and baroreceptor reflexes.

Cite This Study

Skinner et al. (2002) studied this question.

synapsesocial.com/papers/6a799c0902ab7a73dd02725e https://doi.org/10.1038/sj.bjp.0704941

View Full Paper

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Modulation of reflexly evoked vagal bradycardias by central 5‐HT1A receptors in anaesthetized rabbits

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Modulation of reflexly evoked vagal bradycardias by central 5‐HT1A receptors in anaesthetized rabbits

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider