Key result
Microinjection of 5-HT and the 5-HT3 agonist CPBG into the NTS produced a dose-dependent inhibition of the cardiovagal component of the Bezold-Jarisch reflex without affecting sympathetic discharge.
Population
Urethane-anesthetized rats
Comparison
Microinjections into the nucleus tractus… vs Prior local microinjection of 5-HT3 receptor…
Design
Preclinical
Authors
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NTS 5-HT3 modulation of cardiac reflexes in rodents; leaves open translation to human autonomic control.
Stimulation of NTS 5-HT3 receptors inhibits the cardiovagal component of the Bezold-Jarisch reflex without affecting its sympathetic component, suggesting their role in modulating cardiac reflex responses.
Nosjean et al. (1996) studied Bezold-Jarisch reflex. Serotonin (5-HT) and 1-(m-chlorophenyl)-biguanide (CPBG) was evaluated on Atropine-sensitive bradycardiac component of the Bezold-Jarisch reflex. Microinjection of 5-HT and the 5-HT3 agonist CPBG into the NTS produced a dose-dependent inhibition of the cardiovagal component of the Bezold-Jarisch reflex without affecting sympathetic discharge.
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