Why the study?
Does systemic BNP enhance the von Bezold-Jarisch reflex activation of cardiac vagal motoneurons in urethane-anesthetized rats?
Population
Urethane-anesthetized (1.4 g/kg iv) rats (n=15)
Comparison
Intravenous B-type natriuretic peptide infusion… vs Vehicle infusion
Design
Preclinical
Authors
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May modulate vagal reflexes pre-efferently in rats; hypothesis-generating with no immediate clinical implications.
Does systemic BNP enhance the von Bezold-Jarisch reflex activation of cardiac vagal motoneurons in urethane-anesthetized rats?
Systemic BNP enhances the von Bezold-Jarisch reflex activation of cardiac vagal motoneurons by acting before the vagal efferent arm of the reflex pathway.
Toader et al. (2007) studied this question.
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