June 1, 1999Journal of Hypertension
Similar baroreflex bradycardic actions of atrial natriuretic peptide and B and C types of natriuretic peptides in conscious rats
Why the study?
Do natriuretic peptides (ANP, BNP, CNP) enhance baroreflex bradycardia in conscious rats?
Population
Conscious adult Munich-Wistar rats (n=21 total; 10 in ANP dose-response group, 11 in BNP/CNP group)
Comparison
Intravenous infusions of ANP, BNP-32, and CNP-22 vs Vehicle (0.9% saline, 270 microl/h i.v.)
Design
Preclinical
Authors
Discussion
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Implication
Supports natriuretic peptide facilitation of baroreflex bradycardia in conscious rats; hypothesis-generating for human autonomic regulation and should not change practice.
Structured PICO
Do natriuretic peptides (ANP, BNP, CNP) enhance baroreflex bradycardia in conscious rats?
P
Population
Conscious adult Munich-Wistar rats (n=21 total; 10 in ANP dose-response group, 11 in BNP/CNP group)
I
Intervention
Intravenous infusions of ANP (25, 50, 100 pmol/kg/min), BNP-32 (50 pmol/kg/min), and CNP-22 (50 pmol/kg/min)
C
Comparator
Vehicle (0.9% saline, 270 microl/h i.v.)
O
Outcome
Baroreflex bradycardia evoked by rapid intravenous infusions of methoxamine (100 microg/kg)surrogate
ANP, BNP, and CNP all share a common action to facilitate vagal heart rate baroreflexes in conscious rats.
Cite This Study
Thomas et al. (1999) studied this question.