Key result
ANP and BNP outperform CNP for inducing erectile responses and lowering blood pressure.
Why the study?
Natriuretic peptides have been shown to induce penile erection in various species, but their effects on intracavernous pressure and blood pressure in conscious rats require further investigation.
Do natriuretic peptides (ANP, BNP, CNP) increase intracavernous pressure and affect blood pressure in conscious rats?
Do natriuretic peptides (ANP, BNP, CNP) increase intracavernous pressure and affect blood pressure in conscious rats?
ANP and BNP effectively initiate erectile responses and decrease systemic blood pressure in conscious rats, suggesting involvement of the natriuretic peptide receptor-A.
Does not support clinical use in erectile dysfunction; leaves open receptor-A mechanisms for further preclinical investigation.
INTRODUCTION: Natriuretic peptides activate particulate guanylyl cyclases and have been shown to induce penile erection in rats, rabbits, and humans. AIM: We investigated the effects of atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and C-type natriuretic peptide (CNP) on intracavernous pressure (ICP) and systemic blood pressure (BP) in conscious, free-moving rats. METHODS: ICP and BP were measured in male Sprague-Dawley rats after catheters were inserted into the crus corpus cavernosum and carotid artery, respectively. Natriuretic peptides were given by intravenous bolus (3, 10, and 30 nmol/kg) or continuous (0.1 and 1 nmol/kg/minute) administration. MAIN OUTCOME MEASURES: The number of animals with increases in ICP were determined. Amplitudes and durations of ICP responses and changes in BP were also evaluated. RESULTS: More animals had multiple transient increases of ICP in response to ANP and BNP than to CNP. The increases in ICP were transient and appeared to be an "all or none" response. ANP and BNP decreased BP more than CNP, especially with bolus administration. CONCLUSIONS: These findings show that in rats, erectile responses can be initiated by ANP, BNP, and less effectively, by CNP. ANP and BNP have a high affinity for the natriuretic peptide receptor-A, suggesting that this receptor is involved in the responses.
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Aizawa et al. (2008) studied this question. Natriuretic peptides (ANP, BNP, CNP) was evaluated on Number of animals with increases in intracavernous pressure. Atrial natriuretic peptide and brain natriuretic peptide initiated erectile responses and decreased blood pressure more effectively than C-type natriuretic peptide in conscious rats.
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