Key result
Natriuretic peptides increase testicular blood flow in a dose-dependent manner blocked by ANP antagonism.
Why the study?
The role of atrial, brain, and C-type natriuretic peptides in regulating testicular microcirculation and their localization within the testis was unclear.
Natriuretic peptides (ANP, BNP, CNP) increase testicular blood flow and are localized within specific testicular cells, suggesting a role in local microcirculation regulation.
Natriuretic peptides may regulate testicular microcirculation; leaves open any role in human reproductive vascular physiology.
The effect of local injection of atrial (ANP), brain (BNP) and C-type (CNP) natriuretic peptides and an ANP antagonist (HS-142-1) on testicular microcirculation and vasomotion was studied using laser Doppler flowmetry. The natriuretic peptides were also localized immunohistochemically within the testis. ANP, BNP-32, CNP-22 and CNP-53 all caused a dose-related increase in testicular blood flow. The effect of ANP was blocked by concomitant injection of the ANP antagonist. Immunoreactive (ir) CNP and ir BNP were found in Leydig cells whereas in ANP was observed in the seminiferous tubules. It is suggested that the natriuretic peptides could play a role in local regulation of the testicular microcirculation.
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Collin et al. (1997) studied this question. Local injection of atrial (ANP), brain (BNP) and C-type (CNP) natriuretic peptides vs. ANP antagonist (HS-142-1) was evaluated on Testicular blood flow. Local injection of ANP, BNP-32, CNP-22, and CNP-53 caused a dose-related increase in testicular blood flow, which was blocked by an ANP antagonist.
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