September 1, 1990Clinical and Experimental Pharmacology and Physiology

Characteristics of Cardiovascular Reflexes Originating From 5‐ht3 Receptors in the Heart and Lungs of Unanaesthetized Rabbits

View Full Paper

Ask AI

Bookmark

Population

Unanaesthetized rabbits

Design

Preclinical

Authors

RERoger G. EvansGeneral Cardiology JLJohn LudbrookSouth Australia Pathology JMJan MichalicekUNSW Sydney

Discussion

Member takes

Implication

Supports 5-HT3-mediated reflex bradycardia in rabbits; leaves open translation to human cardiovascular control.

Structured PICO

Population

Unanaesthetized rabbits

Intervention

Injection of phenylbiguanide (1-PBG) (6.25-400 micrograms) into the left atrium, right atrium or pulmonary artery

Outcome

Changes in heart rate and arterial pressuresurrogate

In unanaesthetized rabbits, 1-PBG selectively excites myocardial and pulmonary afferents via 5-HT3 receptors, causing reflex bradycardia and hypotension primarily through decreased peripheral resistance.

Cite This Study

Evans et al. (1990) studied this question.

synapsesocial.com/papers/6a854487ff13e6e4e743dcd6 https://doi.org/10.1111/j.1440-1681.1990.tb01367.x

View Full Paper

Ask AI

Bookmark

Characteristics of Cardiovascular Reflexes Originating From 5‐ht3 Receptors in the Heart and Lungs of Unanaesthetized Rabbits

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Characteristics of Cardiovascular Reflexes Originating From 5‐ht3 Receptors in the Heart and Lungs of Unanaesthetized Rabbits

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider