Population
Anesthetized cats (n=10)
Comparison
Phenylbiguanide 40 microgram/kg administered via… vs Baseline physiological state, intact…
Design
Preclinical
Authors
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Hypothesis-generating for abdominal 5-HT3 afferents in ischemia; leaves open any clinical translation or practice change.
Intra-arterial phenylbiguanide induces a pressor response by stimulating 5-HT3 receptors associated with ischemically sensitive abdominal sympathetic afferents, contrasting with the depressor response typically seen with left ventricular administration.
Fu et al. (1998) studied this question.
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