Population
Rats (in vivo model for evaluating cardiopulmonary and arterial baroreceptor reflexes)
Comparison
Intravenous phenyl biguanide infusion at 6… vs Control during volume expansion or baroreceptor…
Design
Preclinical
Authors
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May implicate cardiac serotonin in volume retention; hypothesis-generating in animals and leaves open human translation.
Subthreshold stimulation of 5-HT3-serotonergic cardiopulmonary chemoreceptors blunts the decrease in renal sympathetic nerve activity in response to volume loading, suggesting a mechanism for volume retention when cardiac serotonin is increased.
Veelken et al. (1996) studied this question.
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