Key result
Intravenous phenyl biguanide triggers cardiopulmonary reflex responses via deep cardiac rather than epicardial receptors.
Why the study?
The specific roles of pulmonary and cardiac receptors in mediating reflex responses to phenyl biguanide infusion in conscious rabbits were unclear.
Does phenyl biguanide infusion mediate depressor responses via cardiac or pulmonary receptors in conscious rabbits?
Population
Conscious rabbits
Comparison
Responses before and after lung denervation (LDX) and cardiac nerve blockade (CDX)
Design
Physiological study with selective denervation and nerve blockade
Authors
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Cardiac receptors mediate PBG reflexes in rabbits; leaves open translation to human cardiorespiratory physiology.
Does phenyl biguanide infusion mediate depressor responses via cardiac or pulmonary receptors in conscious rabbits?
In conscious rabbits, the reflex respiratory and cardiovascular responses to phenyl biguanide are mediated by cardiac receptors rather than pulmonary receptors.
Bell et al. (1993) studied this question. Phenyl biguanide (PBG) infusion was evaluated on Breathing frequency, arterial pressure, heart rate, and renal sympathetic nerve activity. In conscious rabbits, intravenous phenyl biguanide infusion produced tachypnea, hypotension, and bradycardia mediated by cardiac receptors not accessible from the epicardial surface.
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