Key result
The rank order of potency for evoking the pulmonary chemoreflex was 5-HT > PBG > PG > PDG, with all responses antagonized by the 5-HT3 receptor antagonist MDL 72222.
Why the study?
Do phenylbiguanide, phenyldiguanide, phenylguanidine, and 5-hydroxytryptamine evoke the pulmonary chemoreflex via 5-HT3 receptors in anaesthetized rabbits?
Population
Pentobarbitone-anaesthetized rabbits
Comparison
Phenylbiguanide, phenyldiguanide… vs Comparison between different agonists and…
Design
Preclinical
Authors
Loading...
PBG preferred over PDG for 5-HT3 pulmonary chemoreflex studies in rabbits; extends agonist characterization but leaves translation open.
Do phenylbiguanide, phenyldiguanide, phenylguanidine, and 5-hydroxytryptamine evoke the pulmonary chemoreflex via 5-HT3 receptors in anaesthetized rabbits?
Phenylbiguanide, not phenyldiguanide, is the appropriate agonist for identifying non-myelinated pulmonary vagal afferents and evoking the pulmonary chemoreflex via 5-HT3 receptors in rabbits.
Kay et al. (1990) studied this question. Phenylbiguanide (PBG), phenyldiguanide (PDG), phenylguanidine (PG) and 5-hydroxytryptamine (5-HT) was evaluated on Pulmonary chemoreflex potency and response to 5-HT3 receptor antagonist MDL 72222. The rank order of potency for evoking the pulmonary chemoreflex was 5-HT > PBG > PG > PDG, with all responses antagonized by the 5-HT3 receptor antagonist MDL 72222.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: