August 1, 1990British Journal of PharmacologyOpen Access

Evidence that central 5‐HT1A‐receptors play a role in the von Bezold‐Jarisch reflex in the rat

Q: What is the clinical evidence from this study?

Study design: Other. Population: von Bezold-Jarisch reflex. Intervention: Intracisternal application of 5-HT1A antagonists (spiperone, methiothepin, pindolol, buspirone) vs. Intravenous application or non-5-HT1A antagonists. Primary outcome: Reflex bradycardia evoked by injection of phenylbiguanide.

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Key result

Intracisternal application of 5-HT1A antagonists reversibly attenuated reflex bradycardia caused by activation of the von Bezold-Jarisch reflex in rats.

Why the study?

Does intracisternal application of 5-HT1A antagonists attenuate reflex bradycardia in the von Bezold-Jarisch reflex in rats?

Population

Anaesthetized, atenolol-pretreated rats

Comparison

Intracisternal application of putative 5-HT1A… vs Intravenous application of the same dose, or…

Design

Preclinical

Authors

RBRichard BogleSt Helier Hospital JPJ.G.P. PiresEscola Superior de Ciências da Santa Casa de Misericórdia de Vitória ARAndrew G. RamageGold Coast Health

Discussion

Member takes

Implication

Supports central 5-HT1A role in reflex bradycardia; hypothesis-generating for human vagal modulation, no clinical translation yet.

Structured PICO

Does intracisternal application of 5-HT1A antagonists attenuate reflex bradycardia in the von Bezold-Jarisch reflex in rats?

Population

Anaesthetized, atenolol-pretreated rats used to investigate the von Bezold-Jarisch reflex.

Intervention

Intracisternal (i.c.) application of putative 5-HT1A antagonists (spiperone 100 micrograms kg-1, methiothepin 200 micrograms kg-1, (+/-)-pindolol 100 micrograms kg-1, buspirone 200 micrograms kg-1)

Comparator

Intravenous (i.v.) application of the same dose (for spiperone), or i.c. application of antagonists selective for alpha 1-adrenoceptors (alfuzosin), 5-HT2-receptors (BW 501C67), or dopamine D2-receptors ((-)-sulpiride)

Outcome

Reflex bradycardia evoked by injection of phenylbiguanide (i.v.)surrogate

Central 5-HT1A receptors play a role in mediating the von Bezold-Jarisch reflex bradycardia in rats.

Cite This Study

Bogle et al. (1990) studied von Bezold-Jarisch reflex. Intracisternal application of 5-HT1A antagonists (spiperone, methiothepin, pindolol, buspirone) vs. Intravenous application or non-5-HT1A antagonists was evaluated on Reflex bradycardia evoked by injection of phenylbiguanide. Intracisternal application of 5-HT1A antagonists reversibly attenuated reflex bradycardia caused by activation of the von Bezold-Jarisch reflex in rats.

synapsesocial.com/papers/6a6b45f134b735385cb3b485 https://doi.org/10.1111/j.1476-5381.1990.tb14088.x

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Evidence that central 5‐HT1A‐receptors play a role in the von Bezold‐Jarisch reflex in the rat

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Evidence that central 5‐HT1A‐receptors play a role in the von Bezold‐Jarisch reflex in the rat

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider