Key result
Vagal afferent-evoked excitation of NTS neurones was attenuated by the selective 5-HT7 antagonist SB 258719, supporting the role of 5-HT neurotransmission in NTS afferent processing.
Population
Anaesthetized rats (extracellular recordings from 104 nucleus tractus solitarius neurones)
Comparison
Ionophoretic application of 5-HT receptor… vs Baseline firing or absence of antagonist
Design
Preclinical
Authors
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5-HT7 receptors participate in NTS afferent processing in rodents; leaves open clinical relevance for human cardiovascular reflexes.
The study demonstrates that 5-HT7 receptors are involved in mediating vagal afferent-evoked excitation of NTS neurones, supporting their role in cardiovascular reflex processing.
Diana et al. (2009) studied this question. 5-HT7 receptor agonist 5-CT and antagonist SB 258719 vs. Baseline / absence of antagonist was evaluated on Firing rate of NTS neurones. Vagal afferent-evoked excitation of NTS neurones was attenuated by the selective 5-HT7 antagonist SB 258719, supporting the role of 5-HT neurotransmission in NTS afferent processing.
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