November 1, 2001AJP Regulatory Integrative and Comparative Physiology

Evidence for α-2 adrenoreceptor modulation of arterial chemoreflexes in the caudal solitary nucleus of the rat

View Full Paper

Ask AI

Bookmark

Population

Urethane-anesthetized rats

Comparison

Bilateral cNTS microinjection of alpha-2… vs Baseline responses before blockade

Design

Preclinical

Authors

LHLinda F. HaywardUniversity of Florida

Discussion

Member takes

Implication

Does not inform clinical chemoreflex modulation; leaves open translation of rat alpha-2 NTS mechanisms to human autonomic control.

Structured PICO

Population

Urethane-anesthetized rats

Intervention

Bilateral cNTS microinjection of alpha-2 receptor antagonists (2 nmol idazoxan or 0.2 nmol yohimbine)

Comparator

Baseline responses before blockade

Outcome

Arterial chemoreflex responses (arterial pressure, renal sympathetic nerve activity, and respiration) to intravenous injections of potassium cyanide (KCN; 75 microg/kg)surrogate

Endogenous activation of alpha-2 adrenoreceptors in the cNTS facilitates central processing of chemoreceptor afferent inputs in rats.

Cite This Study

Linda F. Hayward (2001) studied this question.

synapsesocial.com/papers/6a20b1cb52a81c8a3de52017 https://doi.org/10.1152/ajpregu.2001.281.5.r1464

View Full Paper

Ask AI

Bookmark

Evidence for α-2 adrenoreceptor modulation of arterial chemoreflexes in the caudal solitary nucleus of the rat

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Evidence for α-2 adrenoreceptor modulation of arterial chemoreflexes in the caudal solitary nucleus of the rat

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider