What does this research mean for the field?

Vasoconstrictor responses to chemoreceptor stimulation are potentiated by hypotension and inhibited by transient hypertension, which is mediated at least in part by a central interaction between chemoreceptor and baroreceptor reflexes. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

May 1, 1974Journal of Clinical InvestigationOpen Access

Interaction of Baroreceptor and Chemoreceptor Reflexes MODULATION OF THE CHEMORECEPTOR REFLEX BY CHANGES IN BARORECEPTOR ACTIVITY

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Why the study?

Does the level of arterial pressure and degree of baroreceptor activation modulate vasoconstrictor responses to chemoreceptor stimulation in dogs?

Population

Male mongrel dogs weighing 14-26 kg, anesthetized and paralyzed.

Comparison

Alteration of arterial pressure and isolated… vs Responses to chemoreceptor stimulation at…

Design

Preclinical

Authors

DHDonald D. HeistadOregon National Primate Research Center FAFrançois M. AbboudGeneral Cardiology AMAllyn L. MarkGeneral Cardiology

Discussion

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Implication

Findings in dogs do not inform patient care; leaves open baroreflex-chemoreflex interactions in human cardiovascular control.

Structured PICO

Does the level of arterial pressure and degree of baroreceptor activation modulate vasoconstrictor responses to chemoreceptor stimulation in dogs?

Population

Male mongrel dogs weighing 14-26 kg, anesthetized and paralyzed.

Intervention

Alteration of arterial pressure (hypotension via hemorrhage or transient hypertension via aortic occlusion) and isolated carotid sinus baroreceptor activation during chemoreceptor stimulation (via intracarotid nicotine or hypoxic/hypercapnic blood).

Comparator

Responses to chemoreceptor stimulation at baseline/normal arterial pressure.

Outcome

Vasoconstrictor responses in the innervated gracilis muscle (measured as changes in perfusion pressure at constant flow) and changes in systemic arterial pressure.surrogate

Vasoconstrictor responses to chemoreceptor stimulation are potentiated by hypotension and inhibited by transient hypertension, demonstrating a central interaction between baroreceptor and chemoreceptor reflexes.

Cite This Study

Heistad et al. (1974) studied this question.

synapsesocial.com/papers/6a128d33c031bb6829a6dba7 https://doi.org/10.1172/jci107669

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Interaction of Baroreceptor and Chemoreceptor Reflexes MODULATION OF THE CHEMORECEPTOR REFLEX BY CHANGES IN BARORECEPTOR ACTIVITY

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Interaction of Baroreceptor and Chemoreceptor Reflexes MODULATION OF THE CHEMORECEPTOR REFLEX BY CHANGES IN BARORECEPTOR ACTIVITY

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Also Consider