What does this research mean for the field?

Stimulation of chemoreceptors and baroreceptors activates a vagal cholinergic vasodilator pathway to coronary vessels, mediating reflex coronary vasodilation. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

July 1, 1972Circulation Research

Coronary Vascular Responses to Stimulation of Chemoreceptors and Baroreceptors: EVIDENCE FOR REFLEX ACTIVATION OF VAGAL CHOLINERGIC INNERVATION

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Why the study?

Does stimulation of chemoreceptors and baroreceptors activate a vagal cholinergic vasodilator pathway to coronary vessels in anesthetized dogs?

Population

Anesthetized, artificially ventilated dogs

Comparison

Stimulation of chemoreceptors and baroreceptors vs Responses after bilateral vagotomy or…

Design

Preclinical

Authors

JHJames G. HackettRoyal Bolton Hospital FAFrançois M. AbboudGeneral Cardiology AMAllyn L. MarkGeneral Cardiology

Discussion

Member takes

Implication

Supports vagal cholinergic coronary vasodilation in dogs; leaves open relevance to human physiology and clinical translation.

Structured PICO

Does stimulation of chemoreceptors and baroreceptors activate a vagal cholinergic vasodilator pathway to coronary vessels in anesthetized dogs?

Population

Anesthetized, artificially ventilated dogs

Intervention

Stimulation of chemoreceptors (via carotid and aortic injections of nicotine or cyanide) and baroreceptors (via carotid sinus nerve stimulation)

Comparator

Responses after bilateral vagotomy or administration of atropine

Outcome

Changes in coronary perfusion pressure (reflecting changes in coronary resistance)surrogate

Stimulation of chemoreceptors and baroreceptors activates a vagal cholinergic vasodilator pathway to coronary vessels in dogs.

Cite This Study

Hackett et al. (1972) studied this question.

synapsesocial.com/papers/6a196b4dac919e0a48890eae https://doi.org/10.1161/01.res.31.1.8

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Coronary Vascular Responses to Stimulation of Chemoreceptors and Baroreceptors: EVIDENCE FOR REFLEX ACTIVATION OF VAGAL CHOLINERGIC INNERVATION

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Coronary Vascular Responses to Stimulation of Chemoreceptors and Baroreceptors: EVIDENCE FOR REFLEX ACTIVATION OF VAGAL CHOLINERGIC INNERVATION

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider