Why the study?
What is the mechanism of the rebound increase in coronary blood flow after cessation of cardiac sympathetic nerve stimulation in dogs treated with beta blockers?
What is the mechanism of the rebound increase in coronary blood flow after cessation of cardiac sympathetic nerve stimulation in dogs treated with beta blockers?
This preclinical study aims to elucidate the mechanism of rebound increase in coronary blood flow following sympathetic nerve stimulation in beta-blocked dogs.
Preclinical mechanism study in beta-blocked dogs is hypothesis-generating; leaves open any clinical relevance to human coronary flow.
It has been demonstrated that in anesthetized open-chest dogs pretreated with beta adrenoceptor blocking agents the cardiac sympathetic nerve stimulation produces a decrease in coronary blood flow which is abolished by alpha blockade (1–3). In the same condition a phenomenon of “rebound” increase in coronary blood flow was noticed after cessation of the stimulation (1, 2). The purpose of this communication is to elucidate the mechanism involved in this rebound phenomenon.
No takes yet. Share an insight, caveat, or question.
Takenaka et al. (1972) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: