Why the study?
Does cardiac sympathetic nerve stimulation increase left ventricular contractility (Emax) and plasma norepinephrine in dogs?
Population
12 anesthetized and open-chest dogs
Comparison
40-sec train of electrical cardiac sympathetic… vs Baseline (before CSN stimulation)
Design
Preclinical
Authors
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Hypothesis-generating for sympathetic control of LV contractility in canines; human studies needed before clinical translation.
Does cardiac sympathetic nerve stimulation increase left ventricular contractility (Emax) and plasma norepinephrine in dogs?
Cardiac sympathetic nerve stimulation enhances left ventricular contractility, which correlates linearly with arterial plasma norepinephrine concentration in a canine model.
Murakami et al. (1997) studied this question.
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