April 1, 1988AJP Regulatory Integrative and Comparative Physiology

Epinephrine release from the heart during left stellate ganglion stimulation in dogs

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Population

10 anesthetized dogs

Comparison

1-min period of electrical stimulation of the… vs Immediately before stimulation (baseline control)

Design

Preclinical

Follow-up

1 minute

Authors

FPFrançois PéronnetUniversity of British Columbia RNRéginald NadeauRoche (Switzerland)GBGuy BoudreauCentre Hospitalier de l’Université de Montréal

Discussion

Member takes

Implication

Supports epinephrine cotransmitter hypothesis in canine myocardium; leaves open translation to human sympathetic regulation.

Structured PICO

Population

10 anesthetized dogs

Intervention

1-min period of electrical stimulation of the left stellate ganglion (4 V, 4 ms, 10 Hz)

Comparator

Immediately before stimulation (baseline control)

Outcome

Plasma epinephrine (E) and norepinephrine (NE) concentrations in aorta (Ao) and coronary sinus (CS)surrogate

Electrical stimulation of the left stellate ganglion in dogs causes a significant output of epinephrine from the myocardium, supporting the hypothesis that endogenous tissue epinephrine acts as a cotransmitter of sympathetic fibers.

Cite This Study

Péronnet et al. (1988) studied this question.

synapsesocial.com/papers/6a78ca09e5601668f501f190 https://doi.org/10.1152/ajpregu.1988.254.4.r659

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Epinephrine release from the heart during left stellate ganglion stimulation in dogs

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Epinephrine release from the heart during left stellate ganglion stimulation in dogs

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider