Key result
Prolonged epinephrine infusion (180 min) significantly potentiated the stimulation-induced release of norepinephrine from the myocardium in anesthetized dogs.
Why the study?
Does epinephrine infusion modulate stimulation-induced norepinephrine release from cardiac sympathetic nerves in anesthetized dogs?
Population
Anesthetized dogs
Comparison
Epinephrine infusion for short-term and… vs Control conditions
Design
Preclinical
Authors
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Caution warranted against clinical extrapolation from dogs; leaves open presynaptic beta-2 facilitation of cardiac norepinephrine release in humans.
Does epinephrine infusion modulate stimulation-induced norepinephrine release from cardiac sympathetic nerves in anesthetized dogs?
Prolonged epinephrine infusion increases tissue epinephrine and potentiates norepinephrine release via presynaptic beta 2-adrenoceptors in cardiac sympathetic nerves.
Boudreau et al. (1993) studied Anesthetized dogs (animal model). Epinephrine infusion vs. Control conditions was evaluated on Stimulation-induced release of norepinephrine. Prolonged epinephrine infusion (180 min) significantly potentiated the stimulation-induced release of norepinephrine from the myocardium in anesthetized dogs.
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