Key result
Intravenous infusion of /kg of norepinephrine in unanesthetized dogs sensitized the heart to catecholamines, inducing ventricular tachycardia and myocardial fatty changes for 2-4 days.
Why the study?
Does intravenous infusion of large doses of norepinephrine or epinephrine induce ventricular arrhythmias and myocardial fatty changes in unanesthetized dogs?
Does intravenous infusion of large doses of norepinephrine or epinephrine induce ventricular arrhythmias and myocardial fatty changes in unanesthetized dogs?
Large doses of norepinephrine or epinephrine induce transient myocardial fatty changes and sensitize the heart to ventricular arrhythmias in a canine model.
Answers are grounded in this paper and cite their sources.
Hypothesis-generating for catecholamine cardiotoxicity in intact models; should not change clinical norepinephrine use.
An intravenous infusion of a large dose (0.51 mg/kg) of norepinephrine sensitizes the heart to the action of catechol amines for a period of 2–4 days. During this period, small doses of either epinephrine or norepinephrine induce ventricular tachycardia. In dogs killed the day after infusion, frozen sections of the myocardium stained with Oil red O reveal fatty changes, the severity of which roughly parallels that of the induced tachycardias. Fatty changes were still present in the hearts of dogs killed the 3rd day after infusion, but were negligible 5 days after infusion. Similar, but less marked, cardiac effects were elicited by infusions of large doses of epinephrine.
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Maling et al. (1958) studied this question. Norepinephrine and Epinephrine was evaluated on Ventricular tachycardia and myocardial fatty changes. Intravenous infusion of /kg of norepinephrine in unanesthetized dogs sensitized the heart to catecholamines, inducing ventricular tachycardia and myocardial fatty changes for 2-4 days.
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