Why the study?
Does chronic norepinephrine infusion alter left ventricular functional reserve in conscious dogs?
Population
Conscious dogs instrumented to measure LV wall function, LV internal base diameter, and LV pressures
Comparison
Continuous norepinephrine infusion at 0.5… vs Baseline/normal state before chronic…
Design
Preclinical
Follow-up
28 days
Authors
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Norepinephrine-driven hypertrophy may spare functional reserve in dogs; leaves open translation to human HF phenotypes.
Does chronic norepinephrine infusion alter left ventricular functional reserve in conscious dogs?
Chronic elevation of norepinephrine in dogs induces myocardial hypertrophy without compromising left ventricular functional reserve.
Stewart et al. (1992) studied this question.
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