Key result
Norepinephrine infusion over 3 months in dogs increased beta-receptor numbers twofold to threefold in the ventricles and septum, and increased adenylate cyclase sensitivity in the septum.
Why the study?
Does long-term norepinephrine infusion alter beta-adrenergic receptors and cyclic AMP in the canine ventricular septum?
Population
Canine model (dogs)
Comparison
Norepinephrine infusion to subhypertensive… vs Normal unperturbed state (before infusion)
Design
Preclinical
Follow-up
3 months
Authors
Loading...
Hypothesis-generating for adrenergic signaling in canine hypertrophy models; leaves open relevance to human cardiomyopathy.
Does long-term norepinephrine infusion alter beta-adrenergic receptors and cyclic AMP in the canine ventricular septum?
Long-term norepinephrine infusion in dogs alters the myocardial adrenergic system, suggesting that depleted cyclic AMP and/or ATP may be involved in the development of hypertrophic cardiomyopathy.
Raum et al. (1983) studied Hypertrophic cardiomyopathy. Norepinephrine infusion vs. Normal unperturbed state (baseline) was evaluated on Beta-receptor number and adenylate cyclase activity. Norepinephrine infusion over 3 months in dogs increased beta-receptor numbers twofold to threefold in the ventricles and septum, and increased adenylate cyclase sensitivity in the septum.
Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context: