Key result
Chronic subhypertensive norepinephrine in dogs induces physiologic hypertrophy, progressing to pathologic cardiomyopathy after 6 months.
Population
Isolated myocardial cells and conscious, free-roaming dogs
Design
Preclinical
Follow-up
up to >6 months
Authors
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Provides a time-dependent canine hypertrophy model; leaves open translation to human hypertrophic cardiomyopathy.
Chronic subhypertensive norepinephrine infusion in canine models demonstrates a time-dependent progression from physiologic to pathologic ventricular hypertrophy, providing a model for studying hypertrophic cardiomyopathy.
Michael M. Laks (2009) conducted a review in Ventricular hypertrophy. Chronic infusion of norepinephrine was evaluated on Ventricular hypertrophy (physiologic vs pathologic). Chronic subhypertensive infusion of norepinephrine in dogs produced physiologic ventricular hypertrophy after 3 to 4 months and pathologic hypertrophic cardiomyopathy after more than 6 months.
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