Why the study?
Does chronic elevation of plasma norepinephrine alter the function and structure of the heart in dogs?
Population
Mongrel dogs chronically instrumented for measurement of arterial and left ventricular pressures, left…
Comparison
Continuous infusion of norepinephrine via… vs Baseline measurements before norepinephrine…
Design
Preclinical
Follow-up
28 days
Authors
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Models norepinephrine-driven hypertrophy and beta-desensitization in dogs; leaves open translation to human HF progression and therapy.
Does chronic elevation of plasma norepinephrine alter the function and structure of the heart in dogs?
Chronic adrenergic stimulation induces concentric hypertrophy and reduces beta-receptor coupling to the contractile response without compromising baseline left ventricular function.
Patel et al. (1991) studied this question.
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