Why the study?
Does intravenous norepinephrine alter the inotropic response in conscious dogs during the development and stable phases of perinephritic hypertension?
Population
9 conscious chronically instrumented dogs before and early in the development of perinephritic hypertension…
Comparison
Intravenous infusions of norepinephrine vs Control period
Design
Preclinical
Follow-up
Approximately 14 weeks
Authors
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Suggests caution with norepinephrine during hypertension development; challenges anesthetized data and leaves open human translation.
Does intravenous norepinephrine alter the inotropic response in conscious dogs during the development and stable phases of perinephritic hypertension?
In conscious dogs, the inotropic response to beta-adrenergic stimulation is enhanced selectively during the development of perinephritic hypertension and maintained during stable hypertension, contrasting with prior findings in anesthetized animals.
Shannon et al. (1991) studied this question.
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