Key result
Early renovascular hypertension in dogs maintains beta-adrenergic responses without myocardial desensitization.
Population
18 dogs (10 with early stage one-kidney renal hypertension, 8 sham-operated normotensive dogs)
Comparison
Blood pressure reduction with pinacidil and… vs Sham-operated normotensive dogs
Design
Preclinical
Authors
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Preserved beta-adrenergic responsiveness in this canine model; leaves open reflex-arc defects for targeted mechanistic studies.
Blunted sympathetic reflex responses in early renovascular hypertension are not due to myocardial beta-adrenergic receptor desensitization, indicating the defect lies elsewhere in the reflex arc.
Davidson et al. (1987) studied Early renovascular hypertension (n=18). Early renovascular hypertension vs. Sham-operated normotensive dogs was evaluated on Inotropic and chronotropic responses to beta-adrenergic stimulation and myocardial beta-adrenergic receptor number and adenylate cyclase activity. Dogs with early renovascular hypertension showed preserved chronotropic and inotropic responses to direct beta-adrenergic stimulation and no beta-adrenergic desensitization of the myocardium.
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