Key result
Renal artery stenosis induces canine hypertension without altering pressure or resistance responses to vasoconstrictors.
Why the study?
It was uncertain whether total peripheral resistance and arterial pressure responses to vasoconstrictor agents are amplified during the development of renovascular hypertension in dogs.
Does renal artery stenosis amplify the responses of total peripheral resistance and arterial pressure to vasoconstrictor agents in dogs?
Does renal artery stenosis amplify the responses of total peripheral resistance and arterial pressure to vasoconstrictor agents in dogs?
Hypertension from renal artery stenosis in dogs is driven by nonautonomic, nonangiotensin II mechanisms without vascular amplification of vasoconstrictor effects.
Hypertension from renal artery stenosis develops without altered vasoconstrictor reactivity in dogs; leaves open mechanisms in clinical renovascular disease.
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Anderson et al. (2007) studied Secondary renal hypertension. Renal artery stenosis (1K, 1C hypertension) with or without enalapril vs. Baseline measurements was evaluated on Total peripheral resistance and arterial pressure responses to vasoconstrictor agents (vasopressin and phenylephrine). Renal artery stenosis in dogs induced hypertension without significantly changing the arterial pressure and peripheral resistance responses to vasoconstrictor agents.
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