Population
51 dogs under pentobarbital anesthesia, including 25 with chronic perinephritic hypertension and 26…
Comparison
Hemodynamic assessment of pump-perfused forelimb… vs Normotensive control dogs
Design
Preclinical
Authors
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Suggests structural small-vessel changes in canine hypertension; leaves open translation to human therapy.
Chronic renal hypertension in dogs is associated with increased limb vascular resistance confined to the small vessel segment, partly due to structural changes rather than neural stimuli.
Overbeck et al. (1971) studied this question.
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