Population
44 male mongrel dogs under pentobarbital (35 mg/kg) anesthesia
Comparison
Experimental renal hypertension vs Appropriate normotensive controls (n=22)
Design
Preclinical
Follow-up
8 days to 4 weeks
Authors
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Offers mechanistic insights from canine renal hypertension; leaves open human translation and clinical relevance.
Early experimental renal hypertension in dogs is characterized by elevated arteriolar resistance and reduced venous compliance, without an increase in skin and skeletal muscle blood flow.
H. W. Overbeck (1972) studied this question.
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