Why the study?
Does intravenous volume load affect cardiopulmonary hemodynamics differently in dogs with chronic renal hypertension compared to normotensive dogs?
Population
18 awake dogs with chronic one-kidney, one-wrapped hypertension and 9 normotensive control dogs
Comparison
Intravenous volume load vs Normotensive control dogs and baseline resting…
Design
Preclinical
Authors
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Reduced left atrial distensibility may underlie blunted Bainbridge reflex in hypertension; leaves open relevance to human volume regulation.
Does intravenous volume load affect cardiopulmonary hemodynamics differently in dogs with chronic renal hypertension compared to normotensive dogs?
Decreased distensibility of the left atrium, rather than decreased venous distensibility, may play a role in the attenuated Bainbridge effect in chronic renal hypertension.
Simon et al. (1984) studied this question.
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