December 1, 1981Clinical Science
Contribution of Stenosis Resistance to the Rise in total Peripheral Resistance during Experimental Renal Hypertension in Conscious Dogs
Why the study?
Does experimental renal artery stenosis increase total peripheral resistance and blood pressure in uninephrectomized conscious dogs?
Population
Uninephrectomized conscious dogs
Comparison
Mild, moderate and severe renal artery stenosis… vs Control values (baseline and 24 h after deflation)
Design
Preclinical
Follow-up
3 days of stenosis, 24 hours post-deflation
Authors
Discussion
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Implication
Systemic vasoconstriction drives most resistance rise in this renovascular model; leaves open translation to human renal artery stenosis.
Key Points
- To determine the direct mechanical contribution of renal artery stenosis resistance compared to systemic vascular resistance during the development of renovascular hypertension.
- Induced mild, moderate, or severe renal artery stenosis in uninephrectomized conscious dogs using an inflatable arterial cuff calibrated to maintain distal pressures of 60, 40, or 20 mmHg over 3 days.
- Tracked hemodynamic variables, including arterial blood pressure, cardiac output, total renal resistance, total peripheral resistance, and plasma renin activity during progressive stenosis and 24 hours post-deflation.
- Moderate and severe stenosis significantly elevated blood pressure and total peripheral resistance without altering cardiac output, with physical stenosis resistance accounting for 36% and 26% of the rise in total peripheral resistance, respectively.
- Vasoconstriction in non-renal systemic vascular beds accounted for the remaining 64% to 74% of the rise in total peripheral resistance in moderate and severe stenosis.
- Plasma renin activity and blood pressure elevations correlated directly with stenosis severity and fully returned to baseline values 24 hours after cuff deflation.
Structured PICO
Does experimental renal artery stenosis increase total peripheral resistance and blood pressure in uninephrectomized conscious dogs?
P
Population
Uninephrectomized conscious dogs
I
Intervention
Mild, moderate and severe renal artery stenosis induced by inflating a renal artery cuff to lower distal pressure to 60, 40 or 20 mmHg respectively, progressively narrowed over 3 days
C
Comparator
Control values (baseline and 24 h after deflation)
O
Outcome
Changes in blood pressure, plasma renin activity, total renal resistance to flow, cardiac output, and total peripheral resistancesurrogate
In experimental renal hypertension, the resistance of the stenosis itself accounts for one-quarter to one-third of the increase in total peripheral resistance, with the rest due to non-renal vasoconstriction.
Cite This Study
Anderson et al. (1981) studied this question.