Acute angiotensin II-mediated restoration of distal renal artery pressure in renal artery stenosis and its relationship to the development of sustained one-kidney hypertension in conscious dogs.
Why the study?
Does angiotensin II mediate the restoration of distal renal artery pressure following graded renal artery stenosis in conscious dogs?
Population
Conscious, chronically instrumented dogs
Comparison
Graded renal artery stenosis with or without… vs Baseline state or stenosis without converting…
Design
Preclinical
Follow-up
up to 7 days
Authors
Discussion
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Member takes
Implication
Confirms angiotensin II mediation in conscious dogs; leaves open translation to human renovascular hypertension.
Structured PICO
Does angiotensin II mediate the restoration of distal renal artery pressure following graded renal artery stenosis in conscious dogs?
P
Population
Conscious, chronically instrumented dogs
I
Intervention
Graded renal artery stenosis (rapid reduction in distal renal artery pressure to 60, 40, or 20 mm Hg) with or without converting enzyme inhibitor pretreatment
C
Comparator
Baseline state or stenosis without converting enzyme inhibitor pretreatment
O
Outcome
Renal and systemic hemodynamics (renal artery pressure, vascular resistance, mean aortic pressure) and plasma renin activity (PRA)surrogate
Angiotensin II plays a critical role in the acute restoration of distal renal artery pressure following renal artery stenosis in conscious dogs.
Cite This Study
Anderson et al. (1979) studied this question.