Key result
Treatment with the nonapeptide Pyr-Trp-Pro-Arg-Pro-Gln-Ile-Pro-Pro prevented elevated blood pressure and restored systemic pressure to normal in dogs with experimental renovascular hypertension.
Why the study?
Does the nonapeptide Pyr-Trp-Pro-Arg-Pro-Gln-Ile-Pro-Pro prevent or reduce elevated blood pressure in a dog model of renovascular hypertension?
Population
Trained, unanesthetized unilaterally nephrectomized dogs with renal artery constriction
Design
Preclinical
Authors
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Angiotensin II mediates acute renovascular hypertension in dogs; leaves open translation of ACE inhibition to human therapy.
Does the nonapeptide Pyr-Trp-Pro-Arg-Pro-Gln-Ile-Pro-Pro prevent or reduce elevated blood pressure in a dog model of renovascular hypertension?
The study provides strong evidence that the renin-angiotensin system initiates hypertension in renovascular disease by demonstrating that an ACE-inhibiting nonapeptide prevents and reverses blood pressure elevation.
Miller et al. (1972) studied Experimental Renovascular Hypertension. Nonapeptide Pyr-Trp-Pro-Arg-Pro-Gln-Ile-Pro-Pro was evaluated on Blood pressure. Treatment with the nonapeptide Pyr-Trp-Pro-Arg-Pro-Gln-Ile-Pro-Pro prevented elevated blood pressure and restored systemic pressure to normal in dogs with experimental renovascular hypertension.
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