Why the study?
Does angiotensin II antagonism with P-113 reduce blood pressure in rats with unilateral renal artery constriction?
Does angiotensin II antagonism with P-113 reduce blood pressure in rats with unilateral renal artery constriction?
The extent to which angiotensin II supports blood pressure in rats with renal artery constriction is directly related to plasma renin concentration, though angiotensin II antagonism alone does not abolish the hypertension.
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BP reduction with P-113 correlates with renin but does not abolish hypertension; hypothesis-generating for angiotensin II dependence in renovascular models.
Conscious rats which had undergone unilateral renal artery constriction were infused for 1 h with a specific antagonist of angiotensin II, 1-Sar-8-Ala-angiotensin II (P-113). 2. There was a highly significant correlation between the change in blood pressure induced by P-113 and the pre-infusion plasma renin concentration (PRC), regardless of initial blood pressure or the duration of stenosis. However, the blood pressure fall was not significantly greater in nineteen hypertensive rats than in eleven which remained normotensive. P-113 did not abolish the hypertension. 3. The extent to which angiotensin II supports blood pressure in rats with renal artery constriction is directly related to the PRC.
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Helen F. Oates (1976) studied this question.
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