What question did this study set out to answer?

Assess the contribution of the renin-angiotensin system to the pathogenesis of experimental hypertension across multiple rat models by measuring plasma renin and blood pressure responses to an angiotensin II antagonist.

January 1, 1977Japanese Circulation Journal-english EditionOpen Access

Role of renin-angiotensin system in experimental hypertension in rats: Plasma renin and hypotensive effect of angiotensin II antagonist.

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Population

Conscious rats with various types of experimental hypertension

Design

Preclinical

Authors

JYJ. YamamotoHosei University

Discussion

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Implication

Does not support clinical use of angiotensin antagonists in hypertension; leaves open translation of renin-angiotensin dependence to human subtypes.

Key Points

Assess the contribution of the renin-angiotensin system to the pathogenesis of experimental hypertension across multiple rat models by measuring plasma renin and blood pressure responses to an angiotensin II antagonist.
Infused the competitive angiotensin II antagonist 1-Sar-8-Ile-angiotensin II (0.64 μg/min or 3.2 μg/min) into conscious rats across multiple hypertensive models (one- and two-kidney Goldblatt, Loomis, stroke-prone SHR, and stroke-resistant SHR).
Measured baseline plasma renin concentration and evaluated the effects of antagonist re-infusion after furosemide-induced volume depletion in non-responsive cohorts.
Angiotensin II receptor blockade caused a significant blood pressure reduction in two-kidney Goldblatt rats and 7–8-month-old stroke-prone SHR, but produced no statistically significant effect in one-kidney Goldblatt, Loomis, or stroke-resistant SHR models.
Plasma renin concentration correlated significantly with responsiveness to the antagonist in Goldblatt rats and stroke-prone SHR, but showed no correlation in Loomis rats or stroke-resistant SHR.
Furosemide-induced volume depletion markedly elevated plasma renin across all models and unmasked angiotensin II-dependent hypertension in previously non-responsive groups, except 8-month-old stroke-resistant SHR.

Structured PICO

Population

Conscious rats with various types of experimental hypertension (two-kidney Goldblatt, one-kidney Goldblatt, one- and two-kidney Loomis, stroke-prone spontaneously hypertensive rats [SHR], and stroke-resistant SHR)

Intervention

Infusion of 1-Sar-8-Ile-angiotensin II (0.64 μg/min or 3.2 μg/min), with or without furosemide-induced volume depletion

Outcome

Hypotensive effect (fall in blood pressure) and correlation with pre-infusion plasma renin concentrationsurrogate

The renin-angiotensin system is critically involved in maintaining hypertension in two-kidney Goldblatt rats and older stroke-prone SHR, but less so in other experimental models unless volume depleted.

Cite This Study

J. Yamamoto (1977) studied this question.

synapsesocial.com/papers/6a815f732bdcf510039cd808 https://doi.org/10.1253/jcj.41.665

Topics

Hypertension management

View Full Paper

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Implication

Does not support clinical use of angiotensin antagonists in hypertension; leaves open translation of renin-angiotensin dependence to human subtypes.

Role of renin-angiotensin system in experimental hypertension in rats: Plasma renin and hypotensive effect of angiotensin II antagonist.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Role of renin-angiotensin system in experimental hypertension in rats: Plasma renin and hypotensive effect of angiotensin II antagonist.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider