Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
August 1, 1974Circulation ResearchOpen Access

Comparison of Angiotensin II Antagonist and Antiserum Infusion with Nephrectomy in the Rat with Two-Kidney Goldblatt Hypertension

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does angiotensin II antagonist or nephrectomy reduce blood pressure more effectively than angiotensin II antiserum in rats with two-kidney Goldblatt hypertension?

Population

Rats with two-kidney Goldblatt hypertension, including short-term and chronic hypertension models.

Comparison

Angiotensin II antiserum infusion, followed by… vs Comparison between the effects of antiserum…

Design

Preclinical

Authors

HTH. ThurstonUniversity Hospitals of Leicester NHS TrustJSJ. D. SwalesGeneral / Preventive / Lipids

Discussion

Loading...

Member takes

Implication

Supports ischemic kidney renin-angiotensin mediation in rat Goldblatt model; leaves open translation to human renovascular hypertension.

Key Points

  • To determine the mechanisms and relative contributions of the renin-angiotensin system and the ischemic kidney in sustaining elevated blood pressure during short-term and chronic hypertension.
  • Infused angiotensin II antiserum followed by the peptide antagonist 1-Sar-8-Ala-angiotensin II in rats with short-term (<3 weeks) and chronic (>4 months) two-kidney Goldblatt hypertension.
  • Measured mean blood pressure changes after antiserum, antagonist infusion, and subsequent unilateral nephrectomy of the ischemic kidney, alongside monitoring cumulative sodium balance.
  • Antiserum infusion produced a small, nonsignificant reduction in mean blood pressure, whereas the antagonist induced a major reduction, returning blood pressure to normal levels in short-term hypertension and partially lowering it in chronic hypertension.
  • Unilateral nephrectomy reduced blood pressure to mean levels similar to those achieved following antagonist infusion in both hypertensive groups.

Structured PICO

Does angiotensin II antagonist or nephrectomy reduce blood pressure more effectively than angiotensin II antiserum in rats with two-kidney Goldblatt hypertension?

P
Population
Rats with two-kidney Goldblatt hypertension (one renal artery constricted, contralateral kidney intact), including short-term (< 3 weeks) and chronic (> 4 months) hypertension models.
I
Intervention
Angiotensin II antiserum infusion, followed by angiotensin antagonist (1-Sar-8-Ala-angiotensin II) infusion, and subsequent unilateral nephrectomy.
C
Comparator
Comparison between the effects of antiserum, antagonist, and nephrectomy.
O
Outcome
Blood pressure response.surrogate

In a rat model of two-kidney Goldblatt hypertension, an angiotensin II antagonist and nephrectomy similarly reduced blood pressure, suggesting the ischemic kidney sustains hypertension via the renin-angiotensin system.

Cite This Study

Thurston et al. (1974) studied this question.

synapsesocial.com/papers/6a7cc324273accedbda8b393https://doi.org/10.1161/01.res.35.2.325
View Full Paper
Ask AI
Bookmark
Share