Why the study?
Does unclamping reduce blood pressure in nonresponder rats with chronic two-kidney Goldblatt hypertension despite a positive sodium balance?
Population
Rats with chronic, two-kidney Goldblatt hypertension (one renal artery clamped and contralateral untouched)
Comparison
Unclamping of the renal artery with maintenance… vs Sham unclamping with maintenance of a positive…
Design
Preclinical
Follow-up
12 hours
Authors
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Questions sodium balance as key BP driver in this renovascular model; leaves open human relevance.
Does unclamping reduce blood pressure in nonresponder rats with chronic two-kidney Goldblatt hypertension despite a positive sodium balance?
In a rat model of chronic renovascular hypertension, positive sodium balance is not a major pathogenetic factor maintaining high blood pressure in nonresponders to angiotensin inhibitors.
Otsuka et al. (1979) studied this question.
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