Why the study?
Does surgical correction or prolonged blockade of the renin-angiotensin system reduce blood pressure in Goldblatt two-kidney rats with chronic hypertension?
Population
Goldblatt two-kidney rats with hypertension of more than 4 months' duration
Comparison
Surgical correction or prolonged blockade of the… vs Removal of the clipped kidney or prolonged…
Design
Preclinical
Authors
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Challenges renin-angiotensin dependence in chronic renovascular hypertension maintenance; leaves open bradykinin potentiation by ACE inhibitors in this model.
Does surgical correction or prolonged blockade of the renin-angiotensin system reduce blood pressure in Goldblatt two-kidney rats with chronic hypertension?
In chronic renovascular hypertension in rats, blood pressure maintenance appears independent of the renin-angiotensin system, and the hypotensive effect of converting enzyme inhibitors may be due to bradykinin potentiation.
Thurston et al. (1980) studied this question.
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